iMove, the Sanofi VIE Program, is available to citizens of the European Economic Area (EU + Norway, Liechtenstein and Iceland) aged between 18 and 28.

PLEASE NOTE that since this program is primarily an international development program, candidates cannot apply to a VIE assignment in their own country of citizenship.

PLEASE NOTE that applications that are only submitted in French cannot be considered by our non-French speaking partners at Sanofi worldwide.

Therefore, only applications that are submitted in English will be considered.

At Sanofi diversity and inclusion is foundational to how we operate and is embedded in our Core Values. We respect the diversity of our people, their backgrounds and experiences. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our employees, patients and customers.

We are looking for: Bioprocess Scientist - VIE Contract (W/M)

Target start date: 01/03/2024

Job description

• Maintain and enhance the scientific expertise in industrial upstream & downstream processes.
• Optimize and characterize the antigen production processes (upstream) and the processing of the antigens (downstream).
• Ensure the robustness, reliability, scalability, and cost effectiveness of the overall processes.
• Test and implement new technologies/processes where appropriate.

Responsibilities:

Management (20%):

• Network with local and global experts/ SPPs as necessary, leveraging knowledge/data where possible
• Assist with the discussions and interactions with the regulatory agencies where required
• In coordination with the MTech lab manager, coordinate technologists activities
• Expected 30 to 50% of presence time in the lab

Upstream Process, Troubleshooting and Technology Evaluation (40%):

• Deep knowledge in microbiology and in microbial metabolism
• Proven track record in industrial fermentation process development (batch, fed-batch, continuous) and technology:
• From 100mL up to at least 150L scale
• High cell density culture
• Evaluation/suitability of use of SUF solutions
• Process scale up/scale down
• Prepare risk assessment and gap analysis      
• Be a creative force to bring new, pragmatic, and holistic approach to process development & troubleshooting
• Critical analysis of processes and proactively seek for solutions facilitating the downstream processing of the antigens
• Technological survey
• Improve the use of PAT for process monitoring and analysis

Project & Transversal Interactions (30%):

• Responsible for delivering against agreed-upon project objectives and to the agreed-upon quality standards
• As an Expert in biotechnological processes, ensure that the technical proposals are in accordance with the industrial constraints, are robust, reliable, and economically advantageous
• Ensure that process bottlenecks are identified
• Strive to establish reliable scale-down model of the processes implemented in manufacturing
• Work with other groups to identify/understand the opportunities for new and optimized production processes
• Ensure that all innovative or rationalization ideas that could be proposed are within the industrial property policies of the group
• Challenge the scientific content of the studies performed in the MTech lab
• Be a communication and collaboration facilitator between the departments

Raw Materials and Media/Downstream (10%):

• Consider risk assessments and gap analysis related to raw materials     
• By identifying metabolic limitations
• By characterizing the antigen expression
• By defining growth medium limiting the use of complex and/or animal origin raw material
• Be a creative force for considering the raw material impact on the downstream process

Compliance And Safety

• Work within the framework of the Manufacturing Technology Team (i.e.: respecting schedule, phase gates, decision processes, design review deadlines, team culture, communication, documents, etc.), with professionalism and transparency, and delivering in a timely manner in accordance with the design and execution schedule requirements
• Ensure operating procedures are current and followed, and site and corporate policies are adhered to:
• Ensure the project is carried out in a safe manner and safety issues are effectively resolved
• Improve safety by a day-to-day presence in the lab
• Supervises and monitors compliance with employment and health and safety legislation to ensure that employees work within the policies, procedures, and regulations applicable to their work
• Participates in the investigation of incidents and work-related illnesses
• Responds promptly to all health and safety concerns or incidents and completes the appropriate documentation in a timely manner
• Takes every reasonable precaution to ensure the health and safety of staff
• Ensures that protective equipment and clothing required is used by staff
• Cooperates and assists the Joint Health and Safety Committee in carrying out its functions
• Advises staff of any potential or actual health and safety hazard of which they are aware

Requirements:

• Minimum MSc., PhD. or equivalent in Biotechnology processes or Chemical Engineering & Microbiology
• Ideally, 1-2 years direct experience in upstream process development in pharma/biotech organization
• Experience in fermentation
• Scale-up/Scale-down, Mass transfer
• Experience in downstream would be an asset.
• General understanding of biopharmaceutical manufacturing, Good Manufacturing
• Ability to write technical reports.
• Team-player, collaborative
• Leadership
• Open-mindedness
• Not afraid to speak-up
• Written and oral proficiency in English and French

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.