COMPLETE Principal Scientist OR Associate Director - QSP - Cambridge

Job Description

At Sanofi, a global health care and pharmaceutical company, modeling and simulation approaches support strategy and critical decision making throughout the various phases of drug development.  The Translational Disease Modeling (TDM) group at Sanofi is seeking to hire a highly talented Quantitative Systems Pharmacology (QSP) modeling scientist to support its R&D portfolio. The TDM group is part of Data & Data Sciences department within the R&D organization of Sanofi.

This position is for a modeling scientist to develop and apply mechanism-based approaches of disease modeling. These modeling efforts represent key biological processes of the pathophysiology and a drug’s mechanism of action to enhance the understanding of disease and therapeutic response. QSP-model based simulations allow prediction of drug efficacy in virtual patients to inform clinical translation, and competitive differentiation. The successful candidate will be working within a dynamic, multidisciplinary environment to provide support for strategy and decision making in drug research and development. The position can be based in Cambridge, MA or Bridgewater, NJ. Title will be commeasurable with experience.

This position at Sanofi is an exciting opportunity to chase the miracles of science to improve patient’s lives.

Position Objectives

• Design, build, and apply QSP modeling approaches to support decision making within rare therapeutic area.

Key Responsibilities

• Interface with project team in aligning M&S needs and develop QSP strategy to address needs.

• Develop, and implement innovative mechanistic modeling strategies to support project team M&S needs.

• Communicate modeling predictions to key stakeholders to inform strategy and decision-making.

• Collaborate with internal and external partners (CROs, consultants and academic collaborators) to support internal QSP efforts in key disease areas.

• Identify and interpret preclinical and clinical data critical for model development and refinement.

• Maintain state-of-the art knowledge of relevant modeling approaches and techniques.

• Contribute to abstracts and manuscripts.

• Perform job duties independently with minimal supervision, and mentor others to develop similar capabilities.

Qualifications

• Ph.D. in Biomedical Engineering, Applied mathematics, Systems Biology/Pharmacology or related fields, with 5+ years of mathematical modeling & simulation experience specific for biomedical/pharmaceutical applications (experience within the pharmaceutical industry preferred).

• Track record of productivity, with evidence of independence in leading scientific projects. 

• Hands-on experience with programming languages like Matlab/R/Julia (Matlab preferred).

• Experience in differential equation- based models and parameter optimization approaches.

• Understanding of theory, principles and statistical aspects of mathematical modeling and simulation.

• Good understanding of cell biology and physiology. Understanding of the basic principles of pharmacokinetics and pharmacodynamics also desired.

• Strong written, verbal and interpersonal communication skills. Desire to work within a team environment.

• Strong project management skills including organization, time management and follow-up are key.

Knowledge And Skills Desirable But Not Essential

• Understanding of rare diseases and gene therapy

*Title will be commeasurable with experience.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.