COMPLETE 2024 Co-op – Biopharmaceutics – Modeling and Simulation - Cambridge

The Early Development department provides the CMC expertise to advance projects through early clinical development. As part of the Global CMC Development organization, Early Development is striving to become an industry leader in the development of transformative medicines with scientific excellence and agility. The scope encompasses early formulation for preclinical investigation, biopharmaceutics assessments for oral absorption of small molecules, and risk assessment for translational stage to clinical studies.

We are seeking a highly motivated and detail-oriented CO-OP student to join our team at Sanofi. In this role, you will have the opportunity to work on exciting and challenging projects involving the use of molecular dynamics simulations ad other computational tool to predict drug-excipient interactions and be a part of our digital transformation journey. You will collaborate with cross-functional teams to use our existing and develop and implement novel computational methods and tools to accelerate the discovery and development of new drugs.

Key Responsibilities

• Conduct molecular dynamics simulations to investigate the interactions between drugs and excipients in pharmaceutical formulations

• Develop and validate oral absorption modeling using Gastroplus and/ or simcyp

• Analyze simulation results to predict the stability, solubility, and bioavailability of drugs in different formulations

• Develop and validate computational models and algorithms to predict drug-excipient interactions and optimize formulation designs

• Collaborate with experimentalists to validate simulation results through laboratory experiments

• Work with team members to make best use of our digital lab tool (iLab)

• Collaborate with scientists and leadership team for  various R&D operational and strategic tasks such as data base management, budget management, strategic planning making best use of digital skills

• Communicate findings and insights to cross-functional teams to inform drug development strategies

Preferred Qualifications

• Currently pursuing PhD or MS in a program in Computational Chemistry, Biochemistry, Biophysics, Pharmaceutical Science or a related field

• Strong background in any of the fields of molecular dynamics simulations, computational chemistry, oral absorption modeling and simulation

• Experience with molecular dynamics simulation software

• Strong analytical and problem-solving skills

• Excellent written and verbal communication skills

• Ability to work independently and collaboratively as part of a multidisciplinary team

• Biological sciences, genetic engineering/ engineering sciences with relevant study experience is highly desirable.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.