COMPLETE Global Research Postdoctoral Fellow – Antibody Engineering (YSD) and Structural Biology for Novel Agonistic Antibody Mechanisms - Cambridge

JOB SUMMARY:

We are seeking a highly motivated and talented Postdoctoral Researcher to join our Protein Engineering group within Sanofi LMR (Large Molecule Research) department to work on a novel mechanism of action for agonist antibodies.  This position will work closely with experienced scientists in a dynamic, fast-paced, and highly collaborative environment.  Our Protein Engineering group has a great track record of patents and publications.  We have a state-of-art structural biology capability within the group, offering a unique opportunity to collaborate closely with protein engineers, structural biologists, and computational biologists.

RESPONSIBILITIES:

The successful candidate should have the expertise in the structural biology and yeast display-based antibody/protein engineering. Previous experience in the field of agonist antibodies for immuno-oncology therapeutic area is highly desired. The project will involve a combination of protein production, biochemical/ biophysical characterization, yeast display-based engineering, and structural biology analysis and techniques. The project will focus on expanding the recently discovered mechanism for agonistic antibodies to produce a generic platform modality through antibody engineering and structural biology.

• Design and perform structural biology experiments, such as X-ray crystallography and cryo-EM, to understand the mechanism of action of agonistic antibodies.

• Analyze structures and design structure-based mutations.

• Perform yeast display-based antibody engineering.

• Perform protein expression and purification, and biophysical/biochemical characterization of engineered antibodies, including ELISA, SPR, and mass photometry.

• Analyze and interpret data independently and communicate results to the team and stakeholders.

• Publish research findings in peer-reviewed journals and present at scientific conferences.

REQUIREMENTS:

• Ph.D. in Structural Biology, Biochemistry, Molecular Biology, or related fields.

• Experience with structural biology techniques and protein/antibody design engineering is required.

• Experience with yeast display technology for antibody engineering is highly desired.

• Strong background in protein engineering, molecular biology, and protein purification is highly desired.

• Experience in the field of agonist antibodies for immuno-oncology therapeutic area is desired.

• Ability to work independently, design and execute experiments, troubleshoot technical issues, and analyze and interpret complex data.

• Excellent communication skills and ability to work collaboratively with other team members.

• Strong track record of scientific publications in peer-reviewed journals.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#GD-SA 
#LI-SA

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.