COMPLETE mRNA Principal Scientist - Vaccines - Waltham

In the race for the future of health – The Sanofi mRNA Center of Excellence (CoE)
 
At Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines for more people faster than before.
 
That’s why we’re looking for bold, optimistic world-changers to join the team at our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of more than 600 dedicated employees for it and using it as the foundation to implement integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.
 
Bring your ambition and optimism for the future to Sanofi. Join us!

About the Opportunity:

The Bioanalytical team in Discovery Biology is looking for a skilled, highly motivated, and laboratory-focused Principal Scientist with a passion for applying mass spectrometry-based solutions to scientific challenges encountered in the development of next generation mRNA vaccines.  The successful candidate will focus on implementing and applying novel proteomic strategies in our lab, and will also conduct lipid analyses.  The candidate will collaborate across teams within the Discovery Biology group and with cross-functional teams within the mRNA CoE at Sanofi.

Key Responsibilities:

• Plan, carry out and interpret wet lab proteomic activities for mRNA-LNP mechanism of action studies in biological systems.

• Develop, optimize, and conduct targeted LC-MS quantitative assays for protein quantitation by peptide surrogate.

• Develop, optimize, and carry out sample preparation protocols.

• Operate LC-MS instruments (QE-HF, ZenoToF 7600, Triple Quad 6500+).

• Troubleshoot LC-MS issues, and coordinate preventative maintenance and repairs.

• Author technical reports, study protocols and manuscripts for publication.

• Prepare scientific presentations and report progress at internal and external meetings/conferences.

• Bring forth new ideas and technologies to remain at the forefront of innovation.

• Work closely with cross-functional teams within the mRNA CoE.  Serve as an expert and internal consultant on relevant scientific projects.

Basic Qualifications:

• PhD in Analytical Chemistry or related sciences

• 4+ years of relevant experience in pharma industry.   

• Demonstrated expertise in mass spectrometry characterization and quantitation of proteins, peptides, oligonucleotides, lipids and small molecules (4+ years ideal).

• Mass spec data analysis experience with eg. Xcalibur, Sciex OS, Proteome Discoverer, BioPharma Finder.

• Experience with protein biochemistry and sample preparation techniques.

• Experience developing and optimizing sample preparation methods.

• Experience analyzing and compiling large datasets.

• Excellent interpersonal relationship skills and strong oral/written communication abilities.

• Self-motivated and able to function independently as well as part of a team.

Preferred Qualifications:

• LC-MS experience with lipid analysis

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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