UNIV - Postdoctoral Scholar - Department of Medicine: Division of Hematology Oncology - Charleston

Job Description Summary

The laboratory of Dr. John Wrangle at MUSC Hollings Cancer Center is seeking a postdoctoral scholar to develop bioinformatics tools for studies related to current research in the lab. Under the collective supervision and guidance of Dr. Wrangle and Dr. Stefano Berto (Assistant Professor in Neuroscience and Director of the Bioinformatic Core at MUSC), the successful candidate will plan and execute research projects to inform the development of novel therapeutic approaches for cancer within the field of gene therapy and support other ongoing research projects in the lab. The postdoctoral associate will contribute to NGS analysis projects, and they will work closely with oncologists, biologists, and geneticists in HCC and MUSC developing, implementing, and applying computational tools to analyze, visualize and integrate local and independent next generation sequencing data. The successful candidate will need to be able to write original code for specific applications and also be able to use and tailor existing software tools and analytic pipelines. The candidate will develop new areas and methods of investigation, conduct data analysis, write and publish manuscripts, and present at meetings.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Regular

Cost Center

CC001335 HCC Research & Pilots

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

$0 - $0 - $0

Scheduled Weekly Hours

40

Work Shift

Job Description

Job Duties:

• 30% - Under moderate to minimal supervision, lead bioinformatics design analyses for the development of gene therapy strategies using genetic and transcriptomics datasets from bulk and single-cell RNA sequencing and their integration with other data sources and -omics data.

• 30% - Lead the design and development of software, databases, and pipelines for analyzing and manipulating research data, including proficiency in simple programming using R/Python or Java, statistical programming, and SQL database querying.

• 20% - Provide bioinformatics support to different research projects in the Wrangle lab.

• 10% - Contributes to technical support and works with the entire bioinformatics core team to diagnose and fix issues related to bioinformatics software, databases, and interfaces.

• 5% - May assist in grant and other funding applications, as necessary and appropriate.

• 5% - Performs other responsibilities as required.

Minimum Requirements: A PhD in cell biology, bioinformatics, molecular biology, biochemistry, computer science, or a relevant area of biomedical sciences is required.

Preferred Experience, Skills, and Knowledge: 

• 2-3 years of experience

• Experience in applied NGS data analysis such as Transcriptomics (RNA-seq, scRNA-seq), Genomics (WGS/WES) and Epigenomics (WGBS, ChIP-seq, ATAC-seq); additional experience with other omics methods is a plus.

• Demonstrable experience in programming languages required for data analysis (R and/or Python); Experience with other programming languages is of advantage.

• A solid foundation in statistics.

• Good working knowledge of Unix/Linux/MacOS

• Knowledge and use of cloud computing environments and familiarity with cluster (HPC) compute environments.

• Desirable: Experience building and maintaining bioinformatics tools/pipelines; experience with scientific software development is of advantage.

• Experience scaling to large datasets essential.

Additional Job Description

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent)

Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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